Chuck for sure! My poor baby.

I was going to put Chuck, but..
The majority of the time, Blair has more on her plate ):

First her father left her mother for Roman, then she found out that her best friend slept with her boyfriend, then she slept with her boyfriend's best friend, which lead to him (the boyfriend) breaking up with her, then she found out that Marcus (her current boyfriend) was sleeping with his stepmother and then she was rejected by Yale and had to go to NYU where she doesn't fit.
And also, she has (had?) bulimia and her mother doesn't care much about her.

Wow, that's a lot of "thens" ;P

His mother died while giving birth to him, he had a cold and absent father who he believed blamed him for his mother's death, and then his dad died. So now he's parentless.

Definitely. Nate and Blair's lives have been pretty hard too though.

he is an orphan, and he never felt loved for his parent, so sad.

Blair has more on her plate??

CHUCK IS RUNNING A COMPANY! Blair has french history homework.

The "Chuck's running a company" thing has been going on for what... a month? So I don't really count that as part of his "hard life" yet, lol.

But his family... aw. :(

Blair she has suffering more from every episodes more than any character ..chuck may be in the past but now during this season he has got family and everything work for him

everyone who thinks that blair and chuck have had hard lives do not know what a hard life is.

and Blair and Nate.

and Blair and Nate.

I'm not "counting" Chuck running a company as part of his hard life. I'm counting it as having a lot on his plate. Read the comment above it.

chuck for sure. but blair and nate have pretty hard lives as well.

Hard life means to have to fight for everything in your life!So,yeah,Jenny and Dan own this one.
Chuck`s lif`s bad too `couse of his parents.
And how`s Blair`s life hard,may I ask?Having everything served on a silver plate and complaining about people who don`t see you as a queen?Give me a break...

He's grown up without a mother and when he needed his Dad the most he died.

Nothing is worst than having both parents dead.. I mean, At graduation everyone had there parents there accept.. Chuck (He had Lily but it's not the same)

So next time when you receiving something special or maybe just coming home, Imagine having none of your parents seeing you and seeing them proud of you.