Honestly... Although I loved her season 1 and most of season 2 and even so far this season, I hated her so much in season 3 and I was so disappointed with almost everything she did. There's no way I can't choose Blair.

pretty much what Lauren said.

and Eric.

Blair doesn't really piss me off, as much as she just annoys me.

Definately Serena, she frequently makes the wrong decisions and thinks she can ALWAYS fix things and do things that she wants.... She annoys me so much!
Sometimes Vanessa annoys me too... I don't like her. And also I hated Jenny in season 1 but loved her in season 3, she was so interesting and such a bitch, the only thing i got upset with was when she was trying to steal Nate. :)
Oh, and Nate annoys me too only when he's NOT with Serena. LOL

especially last season but she has always annoyed me a bit. also Chuck and Blair with their constant back and forth love

There are times when I like him, but more often than not he is just plain terrible. Talk about a useless character, he is it.

It's strange, she isn't my least favourite character, but she definitely pisses me off the most. Sometimes I will honestly sit there, watching her and think, What ARE you doing?

Usually,everyone piss me off. But Serena take this hands down.The few episode of season 4 and she has already piss me off with what she does. I mean I don't think she should get to choose between Nate or Dan!
Season 1 FAV: Serena
Season 2 Fav: Blair
Season 3 fav: Jenny
She is my least favorite female

So freaking much.

Don't have to think about it for a second.
All of them have annoyed me,but Blair takes the crown.

Serena,Vanessa and Nate,but Serena be alot better from season 2,but Nate i have never liked,and i hate Vanessa season 1 and 2,she was okey in season 3

Serena is #2 very close to #1
In season 1 Serena was my favorite character

& Blair annoyed me from the start.
all her whining and not getting
what she wants so she has to ruin
someone's life to make herself feel better.
Although she wasn't that bad in S2 im actually
craving for someone to tell Blair off (I want it to be georgina)

I loved him in season 1, but season 3 was just the iceing on the cake.

until season 3, anybody did't really piss me off. Dan was always my least favorite character but I could never say I hated him. I just didn't care about him at all. but in season 3 Blair's been pissing me off in every episode. (that still doesn't make her the least favorite character :D she's great sometimes and I remember how I used to love her)

Not to say that I don't like Nate but he's pissed me off so many times, the way he treats the people around him sometimes really bothers me.
Vanessa was pissing me off in season 1+2 and Serena for around half of season 3.

hate hate hate jenny!!! they should really get her killed off or something!

I've disliked Jenny at some point in all three seasons. I hated Nate in seasons 1 and 2 and I'm not liking him too much now. So he would be second. Then Blair for season 3 alone.

god i cant stand her.

Serena is the one that most consistantly annoyed me through out the series.

I hate Jenny so much

and Vanessa

since the very first episode.

She seems to get every guy she wants and everything she wants even though over people dserve it more then she does.

I guess yeah. She's a good character and I love that she has layers but her cold exterior pisses me off because when she gets hurt she acts like such a baby all the time, IDK. Nate also for no plot almost all the time.

She just can't seem to out grow that party girl and sometimes she comes across bad with the holier than everyone attitude!!

for sure. no doubt

Season 1
She was a complete suck up to Blair and then pourd yogurt on her head and tried to steal her minions.
Season 2
Again tried to be on top and went kinda crazy
Season 3
Thought she was bad a** and AGAIN thought she was better than Blair (even though she clearly wasnt) tried to ruin EVERYONES relationships and she slept with Chuck and then cried about it, feeling sorry for herself!!!!

Jenny, then Serena.

For sure , I hate her!

just hate her