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Patrick Dempsey and Ellen Pompeo (Derek Shepherd and Meredith Grey)
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Eric Dane and Kate Walsh (Mark Sloan and Addison Montgomery)
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Patrick Dempsey and Kate Walsh (Derek Shepherd and Addison Montgomery)
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Chris O'Donnell and Ellen Pompeo (Finn Dandridge and Meredith Grey)
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Justin Chambers and Kate Walsh (Alex Karev and Addison Montgomery)
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Justin Chambers and Katheine Heigl (Alex Karev and Isobel Stevens)
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Justin Chambers and Chyler Leigh (Alex Karev and Lexie Grey)
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Justin Chambers and Sarah Utterbeck (Alex Karev and Olivia)
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Justin Chambers and Elizabeth Reeser (Alex Karev and Rebecca Pope/Ava)
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TR Knight and Sara Ramirez (George O'Malley and Callie Torres)
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TR Knight and Katherine Heigl (George O'Malley and Isobel Stevens)
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TR Knight and Ellen Pompeo (George O'Malley and Meredith Grey)
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TR Knight and Sarah Utterbeck (George O'Malley and Olivia)
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James Pickens Jr and Kate Burton (Richard Webber and Ellis Grey)
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James Pickens Jr and Loretta Divine (Richard and Adele Webber)
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Isisah Washington and Sandra Oh (Preston Burke and Cristina Yang)
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Kevin McKidd and Sandra Oh (Owen Hunt and Cristina Yang)
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Roger Rees and Sandra Oh (Colin Marlow and Cristina Yang)
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Jesse Williams and Sandra Oh (Jackson Avery and Cristina Yang)
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Patrick Dempsey and Lauren Stamile (Derek Shepherd and Rose)
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Jeffrey Dean Morgan and Katherine Heigl (Denny Duquette and Isobel Stevens)
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Eric Dane and Chyler Leigh (Mark Sloan and Lexie Grey)
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Kevin McKidd and Kim Raver (Owen Hunt and Teddy Altman)
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Eric Dane and Kim Raver (Mark Sloan and Teddy Altman)
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Eric Dane and Sara Ramirez (Mark Sloan and Callie Torres)
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Brooke Smith and Sara Ramirez (Erica Hahn and Callie Torres)
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Jessica Capshaw and Sara Ramirez (Arizona Robbins and Callie Torres)
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Jason George and Chandra Wilson (Ben and Miranda Bailey)
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